2026 NFL schedule: Bills stadium debuts Week 2, Cowboys at Giants Week 1, vs. Eagles on Thanksgiving

The Buffalo Bills will play their first regular-season game in their new stadium on September 17, 2026, against the Detroit Lions, opening Amazon Prime Video's Thursday Night Football schedule in Week 2. The 2026 NFL schedule also features the Dallas Cowboys facing the New York Giants in Week 1, and the Philadelphia Eagles hosting a Thanksgiving Day game. The schedule highlights several marquee matchups across the season.