LSU vs. Ole Miss prediction, picks, odds, spread: Lane Kiffin's return to Oxford headlines top-10 showdown

LSU and Ole Miss are set for a top-10 SEC showdown in Oxford, with Lane Kiffin returning to face his former program. The game carries significant College Football Playoff implications, as the winner gains early inside positioning in the CFP race. The matchup is highlighted by Kiffin's bitter departure from Ole Miss, adding a personal storyline to the high-stakes contest.